CBD and the Endocannabinoid system of the body
Health & Wellness

CBD and the Endocannabinoid system of the body

The endocannabinoid system, or shortly called the ECS, is one of our body’s major signaling systems. It provides information and cell-signaling with the help of some specialized receptors found in the brain and lower body. It was first identified in the 1990s and has been well studied since then in relation to its interaction with THC, another highly acclaimed cannabinoid found in the cannabis plant in nature.

Soon after the revelation of CBD, a comparatively newer cannabinoid without higher concertation of THC that gives the euphoric effects to it users, the ECS has been researched upon quite actively, and various strives are being done in order to understand its true working mechanism and its interaction with the CBD in the body. Additionally, with the sudden popularity of various CBD derived products like CBD oils and cbd gummies online and in local markets, and people using them already for their various needs, the research about ECS became that much more important. These studies are also necessary to determine whether the acclaimed medical benefits of CBD are true or not and what implications it might have after its intended use.

What is ECS?

While scientists are still in progress in determining the actual and true nature of the endocannabinoid system, we do know for sure that it performs and regulates various functions in our body. These are :

  • Sleeping
  • Mood and behavior
  • Appetite 
  • Memory and brain
  • Reproduction and fertility

The ECS is a fundamental mechanism in our body and is always present there, working its way around the above problems, whether you use CBD and THC or not.

Its working mechanism

It performs its action suing three main components. These are endocannabinoids, receptors, and enzymes.


Just looking at the name, we can figure out what they actually are. They are molecules, basically like cannabinoids, but the only difference is that they are produced by our bodies. Hence the name endocannabinoids or endogenous cannabinoids. The major endocannabinoid that have been identified so far are:

  • Anandamide or AEA
  • 2-Arachidonoylglyerol or 2-AG

Both these internally produced cannabinoids are crucial in regulating various processes in our body and are produced according to the concentration requirements of the body.


The receptors are actually the signal carriers for the ECS system, which binds its endocannabinoids to these receptors signal the body that ECS needs to take action. There are two main receptors associated with this system:

  • CB1 receptor, which is mainly found in the brain and central nervous system
  • CB2 which is resent in the peripheral nervous system and immune cells.

The type of action depends upon which receptor does the cannabinoid bind to. To relieve the pain, they interact with CB1 receptors, and for immune system responses and inflammation, they interact with CB2 ones.


Enzymes have the same function as they do in the entire body; they breakdown the endocannabinoids after they have performed their function. The most common enzymes that are found here are:

  • Fatty acid amide hydrolase which breaks down AEA
  • Monoacylglycerol acid lipase which breaks down 2-AG

ECS functions

Although there are various functions that the complicated ECS system is known to perform, scientists still haven’t been able to identify exactly how these functions are performed or regulated. Researches have shown that the ECS system is responsible for:

  • Digestion system and appetite-related problems
  • Metabolism
  • Pain
  • Inflammation
  • Mood
  • Memory
  • Brain cells and nerves
  • Cardiovascular implications
  • Stress and anxiety
  • Motor control
  • Muscular formation
  • Reproduction
  • Liver functions

All in all, the primary responsibility that your endocannabinoid system has is to maintain homeostasis of your body after external influences.

Its interaction with CBD

There are three main possibilities that CBD interacts with ECS in your body and provides the various benefits it is known to show. First, it binds with CB1 and CB2, just like the endocannabinoids. Second, it is believed that CBD reacts with such a receptor that has not even been discovered yet. And lastly, it is mentioned in some researches that CBD helps to sustain the already present endocannabinoids and stops their early breakdown, making them more effective.

Also Read:

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